Modified Sickledex tube test: a specific test for S hemoglobin.
نویسندگان
چکیده
منابع مشابه
Rapid solubility test for detection of hemoglobin S.
Several screening methods for detecting sickling hemoglobins are presently used in the clinical laboratory (1-6). The present procedure depends on the insolubility of reduced hemoglobin S in a 2.24 mol/liter phosphate buffer. The commercially available “Sickledex” (Ortho Diagnostics, Raritan, N.J. 08869) is also thought to be based on this principle (6). Our method was compared with the standar...
متن کاملSpot test for detection of sickling hemoglobin.
We describe a simple, noninstrumental procedure for detecting hemoglobin S in samples of blood on filter paper, with use of small volumes of reagents. The method depends on the differential solubilities of reduced sickling and nonsickling hemoglobin in phosphate solutions (1, 2) or Sickledex reagent’ and the apparent solubilizing effect of urea on reduced hemoglobin S (3). The color of paired p...
متن کاملA modification of the "Sickledex" test for hemoglobin S.
The “Sickledex” test (as described by Diggs et al., in a scientific exhibit, 1968, and marketed by Ortho Diagnostics, Raritan, N. J. 08869) has gained widespread use as a screening method for hemoglobin S (1, 2). Apparently based on the solubility test of Itano (3), it has been shown to be positive with abnormal hemoglobins other than the S hemoglobin (4). Nevertheless, it is a quick, simple sc...
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Background and Aim: Brucellosis is a zoonotic disease and is one of the major health problems in our country. Considering its nonspecific symptoms, diagnosis of this disease is often made by laboratory methods. The purpose of the present study was to compare the sensitivity and specificity of ELISA and a relatively new modified Rose Bengal test in the diagnosis of brucellosis. Material and Meth...
متن کاملA report form for the serial display of laboratory results in small hospitals.
Because Sickledex, like the sickling test, only detects sickle haemoglobin it is imperative that electrophoresis is performed on all positive results. At the same time the rare false positive results due to a dysproteinaemia will be detected. This test is valuable, particularly in the laboratory, where occasional sickling tests are performed and positive control cells are difficult to obtain. L...
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عنوان ژورنال:
- Clinical biochemistry
دوره 4 3 شماره
صفحات -
تاریخ انتشار 1971